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THE PMT PILL

October 24, 2006

A BIRTH control pill that also prevents period pains will be launched next year, it was revealed yesterday.

The drug stops the menstrual cycle and the stomach cramps that go with it.

Called Lybrel, it is the first Pill designed to be taken every day without a break.

Makers Wyeth Pharmaceuticals said: “It has been developed for women who find the need to stop taking the Pill for one week every month inconvenient.

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“It will also help those with hormonal fluctuations, to which this monthly break can contribute.” Lybrel contains oestrogen and progestogen hormones with the doses varying during the month.

Wyeth, a US company, said there is no medical reason why women cannot take the Pill continuously. A spokesman said: “It is totally safe. Of the 187 women in our studies, 99 per cent began their periods within three months of stopping the Pill.”

The Family Planning Association’s Toni Belford said: “Many prefer the reassurance of a monthly cycle but it is completely safe to suppress menstruation for years.

“Its not natural for women to have as many periods as they do now.

“Not so long ago women would have had no periods for years at a time because of child-bearing, pregnancy or breast feeding.”

Wyeth hopes to have its US and European licences granted by the end of the year.

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Birth control: the methods, the effects

October 18, 2006

Never before has one little pharmaceutical creation caused such an uproar. A proper name didn’t even have to be used; it was simply known as “The Pill.� Whoever thought to confer the same status on these little tablets as the Great Pyramids was having quite the telepathic moment.

Who but a great seer could have foreseen a time when most everyone who was anyone in high school and college was on some form of oral contraception?

How many of us wake up every morning and pop a little colored pill? Like candy they come in all sorts of “flavors� and varieties so how about we take a trip into Candy Land.

What is most important in choosing a method is deciding what works best for you. This means taking into account your health, frequency of sexual interaction, as well as several other factors, the most important being which method you are most comfortable with.

Physical barriers are 75 to 99 percent effective at preventing pregnancy. Latex or polyurethane condoms are the primary male condoms used, and, in addition to being effective at preventing pregnancy (84 to 98 percent depending on material), they are also the only method of preventing the transmission of viruses such as HIV, herpes and hepatitis. Lambskin condoms have pores that, while blocking sperm, do not guard against the passage of viruses.

Female condoms are not as popular, nor are they as effective as male condoms (79 to 95 percent effective). They do, however, offer the same convenience, as they can be purchased at most drug stores without a perscription and discarded after a single use.

Diaphragms, intrauterine devices, and cervical caps are other physical barriers that can be used by women, though these require a prescription. A diaphragm is a shallow latex cup that prevents sperm from entering the cervix. It is used with a spermicide and inserted into the vagina before sex. Irritation is a concern, as is toxic shock syndrome, but a benefit many people enjoy is that there is no physical barrier between partners.

Hormonal contraception is fast coming to be relied on by many women as a supplementary contraceptive device (supplement because it does not prevent sexually transmitted diseases), and it comes in several doses, hormone combinations and delivery methods.

Birth control pills have traditionally been combination pills of progestin and estrogen. They are designed this way to simulate a 28-day cycle that is considered normal. Long-term side effects do not seem to be an issue though there are increased risks involved for heart attack, stroke and cardiovascular disease in smokers and women over 35.

The mini pill was introduced in the 1970s and contains only progestin. It has the same success rate (98 percent with proper usage) as the actual pill, and due to the lower hormone content, has been shown to curb the side effects. If a patient forgets to take the pill for a day they are typically told to just take it the next day and the effectiveness will not be compromised.

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The mini pill, however, needs to be taken at the same time every day and if it is taken even three hours later, another method of birth control needs to be employed.

All of these pills prevent ovulation, though there seem to be no long term complications when it comes to fertility. Most women are agreeable to conceive within a year after going off of birth control.

Nuva ring is an insertable hormone delivery method that is available through prescription. It’s convenient because, once in place in the vagina, it releases hormones for three weeks after which it is removed. Time is once again an issue, however, and if it is removed for more than three hours, another form of birth control should be used.

Ortho Evra is a patch delivery system which releases estrogen and progestin into the bloodstream. The FDA recently has placed a new warning on the packaging saying women who use this may be at an increased risk for developing blood clots in the legs or lungs. The patch is thought to be more convenient because it only has to be applied once a week. But it contains substantially more hormones than a daily birth control pill, potentially increasing the severity of side effects of taking these hormones.

Depo Provera is an injectable form of birth control that prevents ovulation, but is more effective than the pill and considered equal to surgical intervention to prevent pregnancy. It is given once every three months by a physician. Though it has a high success rate, it also increases the rate of calcium loss from the bones and should not be used for longer than two years.

A new form of birth control that was just recently approved by the FDA is called Implanon. A synthetic fiber rod about the size of a matchstick is surgically inserted into the arm in an in office procedure and remains in place releasing a low dose of progestin for 3 years. It has been in use in more than 30 countries since 1998 and the success rate translates to less than one pregnancy per 100 women per year. It will be widely available in 2007.

There is a world of options and though options generate confusion they also allow for finding the perfect fit. The Women’s Center, the Health Center and even your own physician will be more than willing to accommodate any questions and concerns.

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More Birth Control Options for Men?

October 16, 2006

Men may soon have new options for safe and effective male contraceptives, such as a birth control pill, a patch, or an implant. According to MSNBC, researchers have had much success over the last five years with testing male hormonal contraceptives (MHC) and a daily pill could be available in five to seven years, with implants possibly arriving even sooner.

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The University of Washington in Seattle has found that a male contraceptive that releases a certain amount of testosterone over a three month period has the potential to be a safe and dependable form of birth control. Like hormonal contraceptives for women, which prevent the body from releasing an egg, male hormonal contraceptives would prevent the production of sperm. Dr. Andrea Coviello, from the Population Center for Research in Reproduction, and fellow researchers have been testing a sustained released, testosterone micro-capsule that consists of a thick liquid injected under the skin. “It largely depends on how funding continues. The technology is there. We know how it would work,” Coviello told MSNBC.

Scientists are also experimenting with a new implant, the intra vas device (IVD), that would block the flow of sperm. The device, which consists of tiny silicone plugs, would be another reversible birth control method for men. While the plugs would be inserted and removed surgically, the procedure is not as permanent as a surgical vasectomy.

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Squeamishness About Birth Control Is A Steady Habit We Should Lose

October 11, 2006

Imagine a world where the spam in your e-mail included not just multiple offers for cheap Viagra but deals on inexpensive birth control.

Can you imagine it? If we’re practically giving away the little blue pill, whose express purpose is to enable or enhance the sex act, then why is birth control for women still such a hot-button issue?

A poll released last week by the state’s Permanent Commission on the Status of Women says 86 percent of people surveyed thought all forms of contraceptives - including the Plan B emergency contraceptive - should be readily available to women.

The poll, “Making Ends Meet,” which is available on the organization’s website at www.cga.ct.gov/PCSW, examines the topics that cause worry for Connecticut residents. Those topics range from job insecurity to finding affordable health and child care and the availability of contraceptives.

“If we’re practically giving away Viagra,” said Barbara Potopowitz, the commission’s public information officer, “why are we trying to present women with so many obstacles” in obtaining birth control? Who are we making suffer? Why are we doing it? As long as birth control is legal in the state, why would a corporation like Wal-Mart drag its feet before it offers emergency contraceptives in its pharmacies? (Not to worry. Earlier this year, after state comptroller Nancy Wyman threatened to exclude the store from the state employees’ insurance network, the behemoth relented.)

If we have a state bird and a state flower, birth control seems to be our state bugaboo, and thus it has always been.

Connecticut, after all, gave the world Anthony Comstock, the rabid anti-vice activist responsible for the federal Comstock Act, which limited what material could be sent through the mail or carried across state lines. Contraband included birth control or other “things intended for immoral use.” Heywood Broun and Margaret Leech, early biographers of Comstock, admitted that they admired the reformer for his wistfulness but said he never really grew up. When he thought of evil, he saw the Devil, an actual red being with horns, tail and a pitchfork. And a condom. No, I made that last part up.

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Connecticut took native son Comstock’s laws far further. Its 1879 anti-birth-control law was by far the nation’s most restrictive and rendered illegal the use of any birth-control device for anyone, married or not. Historians say the law was only rarely enforced, but it served as a balm for part of the constituency. For years, legal challenges to it remained unsuccessful.

Connecticut also gave the world Hilda Crosby Standish, a medical doctor and mother of five who spent her professional life advocating for planned parenthood. By the time Hartford-born Standish came on the scene about 20 years after Comstock’s 1915 death, attitudes against birth control were firmly entrenched. Despite that, Standish ran the state’s first birth-control center, the Maternal Health Center on Retreat Avenue, until it closed in 1940 after staff members at a Waterbury clinic were arrested. Standish continued her fight until her death in 2005.

Only in 1965 did the U.S. Supreme Court erase the state’s last vestige of Comstock’s influence in the landmark privacy case of Griswold v. Connecticut. Estelle Griswold was then executive director of Planned Parenthood of Connecticut, and, in defiance of the law, she and others opened a birth-control clinic in New Haven. They were arrested when they gave provided birth control to a married couple.

Griswold died in 1981. Comstock’s long gone, as is Standish. This simple argument should have been settled long ago, yet here we are, still worried about accessibility to birth control.

How long, oh Lord, how long before women in the Nutmeg State have the final and permanent say in their reproductive destiny? When will the outcome of the sex lives of Yankees be left to the participants themselves?

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Professor works toward a birth control for both sexes

October 10, 2006

Senior Staff Writer
For more than 20 years, Dr. Rajesh Naz has been working on a technique for a fertilization interruptus, which is a body block that could stop sperm at the instant of consummation.
Naz, professor and vice chair for research for the Department of Obstetrics and Gynecology at West Virginia University, is attempting to develop a contraceptive vaccine that would bring a quick, simple and reversible birth control to the world.
“Dr. Naz’s research interests are in the area of testis-specific gene expression, contraceptive vaccine development, fertilization and infertility. His laboratory focuses on delineating sperm-specific antigens that have a role in antisperm antibody-mediated infertility, and can be used for the development of contraceptive vaccines for men and women,” stated WVU’s School of Medicine Web site.
This new contraceptive would avoid the risks that accompany all forms of hormonal contraception and could one day be available to men, he said.
“Pills (birth control) can cause mood swings and all the emotional problems associated with contraceptives,” Naz said.
The increase in world population has motivated Naz, a native of India, to develop alternative birth control methods.
“The population is increasing incredibly fast. The population of India is over one billion people in an area one-third the size of the United States. Most developing countries don’t have birth control methods. I have over 100 cousins back in India in my immediate family,” Naz said.
A population bubble is about to explode, and something needs to be done, Naz said.
Naz is in a race to develop a vaccine that could be the saving grace of not only India, but many other countries.
Naz said that there are more than one million elective abortions in the United States each year.
“Fifty percent of these people who have abortions were using contraceptives,” Naz said.
In 1953, the Federal Drug Administration approved the first birth control method, commonly known as “the pill.” For more than half of a century, there have been no new contraceptives developed.
“I want to have a contraceptive that has long-term use, can be intercourse independent, affordable and infrequent for both men and women. They should have a shared responsibility,” Naz said.

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Still in the early stages of testing, Naz has conducted surveys among women to find out how they feel about sharing birth control responsibilities.
“Eighty-five percent of women said they can’t trust their male partner to take the pill because they (women) are the ones who get pregnant,” Naz said.
Women at this point are not really readily acceptable to let the males help with contraceptive methods, Naz said.
The vaccine that Naz is trying to develop would inhibit sperm from attaching to the egg during intercourse.
“There are five or six receptors total on the head of the sperm. I call them primary and secondary receptors,” Naz said.
In developing this vaccine, the receptors on the head of the sperm would be repressed and would essentially bounce off of the egg and not be able to fertilize it.
“If you stop one receptor, then the others can still bind. It decreases each time you stop one, but all the receptors need to be stopped. I am trying to stop these receptors to make men temporarily infertile,” Naz said.
While Naz is trying to develop a vaccine to make peopl e temporarily infertile, he is hoping that the vaccine will also be able to be used as a diagnosis for treatment of infertility.
Ten percent of women produce antibodies to sperm, making them infertile.
Right now, Naz is at 75 to 85 percent effectiveness in his clinical trials, but does not want to release or test the vaccine on humans until it’s 100 percent effective.
“Vaccines are usually developed for diseases, like polio. I want to make a non-disease, yet 100 percent effective, contraceptive that is long-term and reversible,” Naz said.
If a woman wants to have a baby after taking the vaccine, she only has to wait between 10 and 11 months before it is reversed and she can be fertilized again.
Naz said that he does not know when he is going to move to the next stage of testing on humans.
“It could be a year, or it could be more. I don’t want to test it until I see I’m 100 percent effective in my other trials. It will be no more than a few years,” Naz said.
The contraceptive would be marketed to couples in monogamous relationships.
“Women who are going on dates can not trust a male to take this contraceptive,” Naz said

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