MIRCETTE BIRTHCONTROL

Barr Confirms Non-Final Rejection Notice From Patent and Trademark Office on Duramed’s Reissue Application for SEASONALE(R) ‘032 Patent

May 31, 2006

Barr Pharmaceuticals, Inc. (NYSE: BRL ) today confirmed that Duramed Pharmaceuticals, Inc. has received a Non-Final Rejection notice from the Patent and Trademark Office (PTO) regarding its application for reissue of U.S. Patent 5,898,032 (’032) relating to its SEASONALE® extended-cycle oral contraceptive. A Non-Final Rejection affords the Company with three months to respond to the issues raised by the PTO. The PTO then would have additional time to review the Company’s response and decide whether the application for reissue of the patent should be allowed. While the Company said that it had not had the opportunity to review the correspondence from the PTO, it noted that it would be unlikely, given the timing, that the patent in question could be reissued prior to the September 5, 2006 expiration of Duramed’s regulatory exclusivity on SEASONALE.

“While we are disappointed in the determination by the PTO, we intend to fully review all options available to protect our patentable invention, and will respond to the Non-Final Rejection as quickly as possible,” said Bruce L. Downey, Barr’s Chairman and CEO.

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The forward-looking statements contained in this press release speak only as of the date the statement was made. The Company undertakes no obligation (nor does it intend) to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except to the extent required under applicable law.

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Savient Pharmaceuticals Finalizes Agreement for the Settlement of Mircette(R) Litigation

May 31, 2006

Savient Pharmaceuticals, Inc. (”Savient”) (NASDAQ: SVNTE ), an emerging specialty pharmaceutical company engaged in developing, manufacturing and marketing pharmaceutical products that address unmet medical needs in niche and broader markets, announced today that it has concluded with Barr Pharmaceuticals, Inc. (”Barr”) (NYSE: BRL ), Organon USA Inc. and Organon (Ireland) Ltd. (”Organon”), business units of Akzo Nobel NV (Nasdaq: AKZOY ), an agreement for the settlement of the ongoing patent litigation regarding Barr’s generic version of Mircette®, which Barr markets under the trade name Kariva®. Under the terms of the transaction Barr will acquire the exclusive rights to Organon’s Mircette (Desogestrel/Ethinyl Estradiol) oral contraceptive product.

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Some Birth Control Pills Less Likely to Cause Headaches – Study Links Oral Contraceptives to Migraine and non-Migraine Headaches

May 5, 2006

An article in the journal Neurology indicates that there may be a link between birth control pills and headaches. Women on birth control pills are 40 percent more likely to suffer from migraines, and 20 percent more likely to suffer from non-migraine headaches.

According to a recent report on ABC News, birth control pills can boost estrogen levels up to four times their normal levels. The estrogen levels drop fast near menstruation.

The report said that physicians could prescribe women an estrogen patch to be used two or three days before their period so that levels don’t drop so steeply. This may help explain why women are more susceptible to migraines than men, although the researchers could not find a link between the amount of hormones contained in the pills and headache risk.

Not all pills are the same, according to a Reuters report. Dr. Aegidius pointed out that the Mircette oral contraceptive will cause a slower rate of decline in estrogen. She says this may reduce headache risk. Mircette is currently available in the US, but not Europe.

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May 4, 2006

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